EVALUATION OF THE ACUTE TOXICITY OF LIANA BARK OF LANDOLPHIA OWARIENSIS P. BEAUV. (APOCYNACEAE)
DOI:
https://doi.org/10.29121/granthaalayah.v8.i4.2020.22Keywords:
Apocynaceae, Landolphia Owariensis, Acute Toxicity, LD50Abstract [English]
The objective of this study was to assess the acute toxicity of the decocted bark of the liana bark of L. owriensis P. Beauv. (Apocynaceae) in the Wistar strain rat. The study of acute toxicity was carried out according to the OECD 423 method. This study was carried out up to a limit dose of 5000 mg / kg of body weight. After administration of different oral doses, observations on behavior, respiration, skin effects, response of the sensory nervous system or the gastrointestinal effects of animals were made on the 1st, 2nd, 3rd and 14 days (OECD 423). During 14 days of observation, a decoction of the bark of liana from L. owriensis did not show any mortality or lead to obvious toxicity on the mice at the respective doses of 300, 2000 and 5000 mg / kg. The decoction is not toxic to rats, even in large doses (5000 mg / kg of body weight). Therefore, the vine barks of this plant could be used for effective therapeutic purposes.
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References
African Union. Plan of Action of the Decade of Traditional Medicine (2001 - 2010). Implementation of Decision AHG / DEC.164 (XXXVII) of the Lusaka Conference of Heads of State and Government.
Peter A. G. M., De Smet. An introduction to herbal pharmacoepidemiology. J. Ethnopharm., 38, 1993, 189 - 195. DOI: https://doi.org/10.1016/0378-8741(93)90016-X
World Health Organization Geneva. General methodological principles for research and evaluation in traditional medicine, 2000, 79.
OECD Guideline for the Testing of Chemicals: Acute Oral Toxicity - Acute Toxicity Class Method, No. 423 (2001).
Leblanc, GA. Acute toxicity. In: A Textbook of Modern Toxicology. 4th ed. John Wiley & Sons. Inc (Hoboken, New Jersey), 2010.
Fofana, Y., Dally, LI., Kablan, ALC., Lia, AJ. Phytochemical screening and subacute toxicity assessment of decoction of liana bark of Landolphia owariensis P. Beauv. (Apocynaceae) in wistar rats, 8, 2020, 1, 266-276.
Raponda, W., Sillans R. Useful plants from Gabon.Encyclo-Ed. Paul Lechevaler Paris, 1961, 83-84.
Olson, H., Betton, G., Robinson, D., Thomas, K., Monro, A., Kolaja, G., Lilly, P., Sanders, J., Sipes, G., Bracken, W., Dorato, M., Van, DK., Smith, P., Berger, B., Heller, A. Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals. Regulatory Toxicology and Pharmacology, 32, 2000, 56 - 67. DOI: https://doi.org/10.1006/rtph.2000.1399
El-Hilaly, J., Israili, ZH., Lyoussi, B. Acute and chronic toxicological studies of Ajuga iva in experimental animals. Journal of Ethnopharmacology, 91, 2004, 43-50. DOI: https://doi.org/10.1016/j.jep.2003.11.009
Betti, H.A., Stein C.A., Dallegrave, E., Barth, Wouters A.T., Negrão, W. T., Driemeier, D., Buffon, A., Kuze, M.S. Acute and repeated-doses (28 days) toxicity study of Hypericum polyanthemum Klotzsch ex Reichardt (Guttiferare) in mice.Food and Chemical Toxicology, 50, 2012, 2349-2355. DOI: https://doi.org/10.1016/j.fct.2012.04.012
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