OPTIMIZED MODEL FOR KIDNEY DISEASE CLASSIFICATION USING FINE-TUNED VGG19 VISION TRANSFORMERS AND BAYESIAN OPTIMIZATION
DOI:
https://doi.org/10.29121/shodhkosh.v7.i13s.2026.8434Keywords:
Kidney Disease, Deep Learning, Vision Transformer, Bayesian Optimization, Medical Imaging ProcessAbstract [English]
Kidney disease is a significant global health concern, affecting millions of individuals annually, with its early detection playing a pivotal role in reducing mortality and improving patient outcomes. Traditional diagnostic approaches rely heavily on manual analysis by medical experts, which is often time-intensive and prone to subjectivity. The emergence of advanced deep learning models offers promising alternatives, yet many existing methods struggle with achieving high accuracy and generalizability due to suboptimal model configurations or reliance on limited datasets. To address this gap, this study proposes a fine-tuned VGG19 model optimized using a Grid Search algorithm to enhance kidney disease classification performance using CT scan images. A Grid Search optimization process was applied to fine-tune hyperparameters to maximize model performance. The experimental results demonstrate that the proposed model achieves superior performance metrics, including an accuracy of 98.78%, precision of 98.84%, recall of 98.28%, and an F1-score of 98.55%, outperforming established models like DenseNet201, EfficientNetB0, and SSLSD-KTD. This study provides a significant contribution to kidney disease classification, demonstrating the efficacy of combining fine-tuned deep learning architectures with systematic hyperparameter optimization.
References
Abdeltawab, H., Khalifa, F., Ghazal, M., Cheng, L., Gondim, D., & El-Baz, A. (2021). A pyramidal deep learning pipeline for kidney whole-slide histology images classification. Scientific Reports, 11(1), 20189. https://doi.org/10.1038/s41598-021-99735-6
Alnazer, I., Bourdon, P., Urruty, T., Falou, O., Khalil, M., Shahin, A., & Fernandez-Maloigne, C. (2021). Recent advances in medical image processing for the evaluation of chronic kidney disease. Medical Image Analysis, 69, 101960. https://doi.org/10.1016/j.media.2021.101960
Alzu’bi, D., Abdullah, M., Hmeidi, I., AlAzab, R., Gharaibeh, M., El-Heis, M., Almotairi, K. H., Forestiero, A., Hussein, A. M., & Abualigah, L. (2022). Kidney tumor detection and classification based on deep learning approaches: a new dataset in CT scans. Journal of Healthcare Engineering, 2022, 1–22. https://doi.org/10.1155/2022/3861161
Badawy, M., Almars, A. M., Balaha, H. M., Shehata, M., Qaraad, M., & Elhosseini, M. (2023). A two-stage renal disease classification based on transfer learning with hyperparameters optimization. Frontiers in Medicine, 10. https://doi.org/10.3389/fmed.2023.1106717
Blau, N., Klang, E., Kiryati, N., Amitai, M., Portnoy, O., & Mayer, A. (2018). Fully automatic detection of renal cysts in abdominal CT scans. International Journal of Computer Assisted Radiology and Surgery, 13(7), 957–966. https://doi.org/10.1007/s11548-018-1726-6
CT KIDNEY DATASET: Normal-Cyst-Tumor and Stone. (2021, November 1). https://www.kaggle.com/datasets/nazmul0087/ct-kidney-dataset-normal-cyst-tumor-and-stone
Debal, D. A., & Sitote, T. M. (2022). Chronic kidney disease prediction using machine learning techniques. Journal of Big Data, 9(1). https://doi.org/10.1186/s40537-022-00657-5
Etem, T., & Teke, M. (2024). Enhanced deep learning based decision support system for kidney tumour detection. BenchCouncil Transactions on Benchmarks Standards and Evaluations, 4(2), 100174. https://doi.org/10.1016/j.tbench.2024.100174
Etem, T., & Teke, M. (2024). Enhanced deep learning based decision support system for kidney tumour detection. BenchCouncil Transactions on Benchmarks Standards and Evaluations, 4(2), 100174. https://doi.org/10.1016/j.tbench.2024.100174
Francis, A., Harhay, M. N., Ong, A. C. M., Tummalapalli, S. L., Ortiz, A., Fogo, A. B., Fliser, D., Roy-Chaudhury, P., Fontana, M., Nangaku, M., Wanner, C., Malik, C., Hradsky, A., Adu, D., Bavanandan, S., Cusumano, A., Sola, L., Ulasi, I., Jha, V., . . . Nephrology, I. S. O. (2024). Chronic kidney disease and the global public health agenda: an international consensus. Nature Reviews Nephrology, 20(7), 473–485. https://doi.org/10.1038/s41581-024-00820-6
Gao, P., Ma, T., Li, H., Lin, Z., Dai, J., & Qiao, Y. (2022). CoNVMAE: Masked Convolution meets Masked Autoencoders. arXiv (Cornell University). https://doi.org/10.48550/arxiv.2205.03892
Hussain, S., Songhua, X., Aslam, M., Waqas, M., & Hussain, S. (2024). Quantum Deep Learning for Automatic Chronic Kidney Disease Identification and Classification with CT images. Research Square. https://doi.org/10.21203/rs.3.rs-4743771/v1
K, K. V. Nagaraja, T. Singh and B. P. KN, "Optimization Study of Renal CT Image Classification Using Convolution Neural Networks," 2023 14th International Conference on Computing Communication and Networking Technologies (ICCCNT), Delhi, India, 2023, pp. 1-8, doi: 10.1109/ICCCNT56998.2023.10307772.
Karam, S., Amouzegar, A., Alshamsi, I. R., Ghamdi, S. M. A., Anwar, S., Ghnaimat, M., Saeed, B., Arruebo, S., Bello, A. K., Caskey, F. J., Damster, S., Donner, J., Jha, V., Johnson, D. W., Levin, A., Malik, C., Nangaku, M., Okpechi, I. G., Tonelli, M., . . . Zaidi, D. (2024). Capacity for the management of kidney failure in the International Society of Nephrology Middle East region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA). Kidney International Supplements, 13(1), 57–70. https://doi.org/10.1016/j.kisu.2024.01.009
Kim, M., Yun, J., Cho, Y., Shin, K., Jang, R., Bae, H., & Kim, N. (2019). Deep learning in medical imaging. Neurospine, 16(4), 657–668. https://doi.org/10.14245/ns.1938396.198
Koonce, B. (2021). Convolutional Neural Networks with Swift for Tensorflow. In Apress eBooks. https://doi.org/10.1007/978-1-4842-6168-2
Kulandaivelu, G., Suchitra, M., Pugalenthi, R., & Lalit, R. (2025). An implementation of adaptive Multi‐CNN feature fusion model with attention mechanism with improved heuristic algorithm for kidney stone detection. Computational Intelligence, 41(1). https://doi.org/10.1111/coin.70028
Kumar, Y., Brar, T. P. S., Kaur, C., & Singh, C. (2024). A comprehensive study of deep learning methods for kidney tumor, cyst, and stone diagnostics and detection using CT images. Archives of Computational Methods in Engineering. https://doi.org/10.1007/s11831-024-10112-8
Liashchynskyi, P., & Liashchynskyi, P. (2019, December 12). Grid search, random search, genetic algorithm: A big comparison for NAS. arXiv.org. https://arxiv.org/abs/1912.06059
Lin, Z., Yang, W., Zhang, W., Jiang, C., Chu, J., Yang, J., & Yuan, X. (2023). Recognizing pathology of renal tumor from macroscopic cross-section image by deep learning. BioMedical Engineering OnLine, 22(1), 3. https://doi.org/10.1186/s12938-023-01064-4
M. H. K. Mehedi, E. Haque, S. Y. Radin, M. A. Ur Rahman, M. T. Reza and M. G. R. Alam, "Kidney Tumor Segmentation and Classification using Deep Neural Network on CT Images," 2022 International Conference on Digital Image Computing: Techniques and Applications (DICTA), Sydney, Australia, 2022, pp. 1-7, doi: 10.1109/DICTA56598.2022.10034638.
M. S. Hossain, S. M. Nazmul Hassan, M. Al-Amin, M. N. Rahaman, R. Hossain and M. I. Hossain, "Kidney Disease Detection from CT Images using a customized CNN model and Deep Learning," 2023 International Conference on Advances in Intelligent Computing and Applications (AICAPS), Kochi, India, 2023, pp. 1-6, doi: 10.1109/AICAPS57044.2023.10074314.
Majid, M., Gulzar, Y., Ayoub, S., Khan, F., Reegu, F. A., Mir, M. S., Jaziri, W., & Soomro, A. B. (2023). Enhanced Transfer Learning Strategies for Effective Kidney Tumor Classification with CT Imaging. International Journal of Advanced Computer Science and Applications, 14(8). https://doi.org/10.14569/ijacsa.2023.0140847
N. Narmada, V. Shekhar and T. Singh, "Classification of Kidney Ailments using CNN in CT Images," 2022 13th International Conference on Computing Communication and Networking Technologies (ICCCNT), Kharagpur, India, 2022, pp. 1-5, doi: 10.1109/ICCCNT54827.2022.9984256.
Özbay, E., Özbay, F. A., & Gharehchopogh, F. S. (2024). Kidney Tumor Classification on CT images using Self-supervised Learning. Computers in Biology and Medicine, 176, 108554. https://doi.org/10.1016/j.compbiomed.2024.108554
Özbay, E., Özbay, F. A., & Gharehchopogh, F. S. (2024). Kidney Tumor Classification on CT images using Self-supervised Learning. Computers in Biology and Medicine, 176, 108554. https://doi.org/10.1016/j.compbiomed.2024.108554
Parvaiz, A., Khalid, M. A., Zafar, R., Ameer, H., Ali, M., & Fraz, M. M. (2023). Vision Transformers in medical computer vision—A contemplative retrospection. Engineering Applications of Artificial Intelligence, 122, 106126. https://doi.org/10.1016/j.engappai.2023.106126
Prakash, N. N., Rajesh, V., Namakhwa, D. L., Pande, S. D., & Ahammad, S. H. (2023). A DenseNet CNN-based liver lesion prediction and classification for future medical diagnosis. Scientific African, 20, e01629. https://doi.org/10.1016/j.sciaf.2023.e01629
Razzak, M. I., Naz, S., & Zaib, A. (2017). Deep learning for medical Image Processing: Overview, challenges and the future. In Lecture notes in computational vision and biomechanics (pp. 323–350). https://doi.org/10.1007/978-3-319-65981-7_12
S. D. Pande and R. Agarwal, "Multi-Class Kidney Abnormalities Detecting Novel System Through Computed Tomography," in IEEE Access, vol. 12, pp. 21147-21155, 2024, doi: 10.1109/ACCESS.2024.3351181.
S. Pavarut et al., "Improving Kidney Tumor Classification With Multi-Modal Medical Images Recovered Partially by Conditional CycleGAN," in IEEE Access, vol. 11, pp. 146250-146261, 2023, doi: 10.1109/ACCESS.2023.3345648.
Shanmathi, K., Varshini, S. S., Varsha, M., Indrakumar, S., & PraveenKumar, G. D. (2025). Deep neural network models for comprehensive kidney stone prediction. In Information systems engineering and management (pp. 304–319). https://doi.org/10.1007/978-3-031-90478-3_26
Sharon, J. J., & Anbarasi, L. J. (2025). An attention enhanced dilated bottleneck network for kidney disease classification. Scientific Reports, 15(1), 9865. https://doi.org/10.1038/s41598-025-90519-w
Simonyan, K., & Zisserman, A. (2014, September 4). Very deep convolutional networks for Large-Scale image recognition. arXiv.org. https://arxiv.org/abs/1409.1556
Srivastava, S. S. . R. K. Y., . V. N. ,. P. K. (2022). An Ensemble Learning Approach for Chronic Kidney Disease Classification. www.pnrjournal.com. https://doi.org/10.47750/pnr.2022.13.S10.279
Tadesse, Y. (2026). AI-POWERED SECURITY STRATEGIES FOR THE OSI MODEL. ShodhAI: Journal of Artificial Intelligence, 3(1), 9–19. https://doi.org/10.29121/shodhai.v3.i1.2026.62
Türk, F., Lüy, M., & Barışçı, N. (2020). Kidney and renal tumor segmentation using a hybrid V-Net-Based model. Mathematics, 8(10), 1772. https://doi.org/10.3390/math8101772
Vetrithangam, D., Himabindu, Saranya, Neha, S., Naresh Kumar, P., Fathima, A., Ashok, B., & Akanksha, K. (2024). Improved RESNET models for chronic kidney disease prediction. Journal of Electrical Systems, 20(2s), 165–183. https://doi.org/10.52783/jes.1121
Yildirim, K., Bozdag, P. G., Talo, M., Yildirim, O., Karabatak, M., & Acharya, U. (2021). Deep learning model for automated kidney stone detection using coronal CT images. Computers in Biology and Medicine, 135, 104569. https://doi.org/10.1016/j.compbiomed.2021.104569
Zabihollahy, F., Schieda, N., Krishna, S., & Ukwatta, E. (2020). Automated classification of solid renal masses on contrast-enhanced computed tomography images using convolutional neural network with decision fusion. European Radiology, 30(9), 5183–5190. https://doi.org/10.1007/s00330-020-06787-9
Zain, R. H., Sumijan, & Defit, S. (2025). Development of an ultrasound image extraction method for detection and classification of kidney abnormalities using a convolutional neural network. International Journal of Online and Biomedical Engineering (iJOE), 21(04), 150–170. https://doi.org/10.3991/ijoe.v21i04.53289
Zhao, T., Sun, Z., Guo, Y., Sun, Y., Zhang, Y., & Wang, X. (2023). Automatic renal mass segmentation and classification on CT images based on 3D U-Net and ResNet algorithms. Frontiers in Oncology, 13, 1169922. https://doi.org/10.3389/fonc.2023.1169922
Zheng, Q., Furth, S., Tasian, G., & Fan, Y. (2018). Computer-aided diagnosis of congenital abnormalities of the kidney and urinary tract in children based on ultrasound imaging data by integrating texture image features and deep transfer learning image features. Journal of Pediatric Urology, 15(1), 75.e1-75.e7. https://doi.org/10.1016/j.jpurol.2018.10.020
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Kancharla Anitha, B. Basaveswara Rao

This work is licensed under a Creative Commons Attribution 4.0 International License.
With the licence CC-BY, authors retain the copyright, allowing anyone to download, reuse, re-print, modify, distribute, and/or copy their contribution. The work must be properly attributed to its author.
It is not necessary to ask for further permission from the author or journal board.
This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.






















