HEALING HORIZONS: AI AND ML INNOVATIONS IN PHARMACEUTICALS
DOI:
https://doi.org/10.29121/shodhkosh.v3.i2.2022.2241Keywords:
Artificial Intelligence (AI), Machine Learning (ML), Pharmaceuticals, Drug Discovery, Clinical Trials, Personalized Medicine, Supply Chain Optimization, Predictive Modeling, Healthcare Innovation, Pharmaceutical Industry TransformationAbstract [English]
Artificial Intelligence (AI) and Machine Learning (ML) are transforming the pharmaceutical industry, ushering in an era of efficiency, precision, and personalized treatment. This paper reviews the innovations brought by AI and ML across various stages of pharmaceutical development—from drug discovery and clinical trials to personalized medicine and supply chain optimization. AI-driven algorithms have significantly accelerated drug discovery by identifying potential drug candidates and predicting their efficacy, thus reducing time and costs. ML models are being employed in clinical trial optimization, helping to select suitable candidates, manage data, and predict trial outcomes with greater accuracy. Additionally, AI and ML are enhancing personalized medicine by tailoring treatment plans to individual patient profiles, thereby improving therapeutic effectiveness and minimizing side effects. This paper also explores the role of AI in optimizing pharmaceutical supply chains, streamlining production, and predicting demand, thereby reducing wastage and enhancing efficiency. Despite these advancements, challenges such as data privacy concerns, regulatory hurdles, and the need for large, high-quality datasets persist. This review highlights both the potential and limitations of AI and ML in reshaping the pharmaceutical landscape, emphasizing the need for collaboration between stakeholders—including researchers, regulatory bodies, and pharmaceutical companies—to address existing challenges. The study concludes that AI and ML are poised to play a pivotal role in transforming the pharmaceutical industry, ultimately leading to faster, safer, and more effective treatments. Future research should focus on improving AI transparency and developing robust ethical frameworks to facilitate widespread adoption in pharmaceuticals.
References
Ahn, J., & Kim, H. (2020). The role of artificial intelligence in drug discovery: Opportunities and challenges. Expert Opinion on Drug Discovery, 15(9), 1003-1010. https://doi.org/10.1080/17460441.2020.1786790
Alsentzer, E., Murphy, J. R., Boag, W., Weng, W.-H., Jindi, D., Naumann, T., & McDermott, M. (2019). Publicly available clinical BERT embeddings. Proceedings of the 2nd Clinical Natural Language Processing Workshop, 72-78. DOI: https://doi.org/10.18653/v1/W19-1909
Alvi, M., & Hussain, M. (2021). Machine learning applications in drug design: A comprehensive review. Journal of Computational Chemistry, 42(12), 1180-1193. https://doi.org/10.1002/jcc.26529 DOI: https://doi.org/10.1002/jcc.26529
Bhatt, A. (2020). Artificial intelligence in managing clinical trial design and conduct: Clinical trial development, approvals, and clinical trial results. Perspectives in Clinical Research, 11(4), 142-147. https://doi.org/10.4103/picr.PICR_109_20
Chen, H., & Zhang, Y. (2019). Deep learning for drug discovery and development: A review. Artificial Intelligence in Medicine, 98, 41-48. https://doi.org/10.1016/j.artmed.2019.02.005 DOI: https://doi.org/10.1016/j.artmed.2019.02.005
Chen, L., He, Y., & Liu, T. (2021). Machine learning in pharmaceutical industry: Progress and challenges. Journal of Pharmaceutical Innovation, 16(1), 9-16.
Esteva, A., Robicquet, A., Ramsundar, B., Kuleshov, V., DePristo, M., Chou, K., Cui, C., Corrado, G. S., Thrun, S., & Dean, J. (2019). A guide to deep learning in healthcare. Nature Medicine, 25(1), 24-29. DOI: https://doi.org/10.1038/s41591-018-0316-z
Gao, Y., & Zhang, Y. (2021). Applications of deep learning in drug discovery: Advances and opportunities. Drug Development Research, 82(1), 31-45.
Hinton, G. E., & Salakhutdinov, R. R. (2006). Reducing the dimensionality of data with neural networks. Science, 313(5786), 504-507. https://doi.org/10.1126/science.1127647 DOI: https://doi.org/10.1126/science.1127647
Jha, S. K., & Verma, A. K. (2021). Artificial intelligence and machine learning in pharmaceuticals: A review. Journal of Pharmaceutical Sciences, 110(2), 713-728. https://doi.org/10.1016/j.xphs.2020.12.020 DOI: https://doi.org/10.1016/j.xphs.2020.12.020
Johnson, A. E. W., Pollard, T. J., & Mark, R. G. (2022). Challenges in the deployment of AI systems in healthcare. Journal of the American Medical Informatics Association, 29(3), 400-406.
Kearns, M., & Nevmyvaka, Y. (2019). Applications of machine learning in pharmaceuticals: Transforming drug development. Nature Reviews Drug Discovery, 18(5), 311-312. https://doi.org/10.1038/s41573-019-0025-2
Li, X., & Yu, Y. (2020). The impact of artificial intelligence on pharmaceutical research and development. Pharmaceutical Research, 37(1), 24. https://doi.org/10.1007/s11095-019-2727-4
Markoff, J. (2017). Machines of loving grace: The quest for common ground between humans and robots. HarperCollins.
Mendez, R., & Verma, A. (2018). Leveraging AI in drug discovery and development: A case study. Trends in Pharmacological Sciences, 39(9), 806-818. https://doi.org/10.1016/j.tips.2018.06.002 DOI: https://doi.org/10.1016/j.tips.2018.06.002
Mittelstadt, B. D. (2019). Principles alone cannot guarantee ethical AI. Nature Machine Intelligence, 1(11), 501-507. DOI: https://doi.org/10.1038/s42256-019-0114-4
Pushpakom, S., Iorio, F., Eyers, P. A., Escott, K. J., Hopper, S., Wells, A., Doig, A., Guilliams, T., Latimer, J., McNamee, C., Norris, A., Sanseau, P., Cavalla, D., & Pirmohamed, M. (2019). Drug repurposing: Progress, challenges, and recommendations. Nature Reviews Drug Discovery, 18(1), 41-58. DOI: https://doi.org/10.1038/nrd.2018.168
Saito, H., & Fukuda, Y. (2021). AI-driven drug discovery: Current challenges and future perspectives. Frontiers in Pharmacology, 12, 652. https://doi.org/10.3389/fphar.2021.706176
Senior, A. W., Evans, R., Jumper, J., Kirkpatrick, J., Sifre, L., Green, T., Qin, C., Zidek, A., Nelson, A. W. R., Bridgland, A., Penedones, H., Petersen, S., Simonyan, K., Crossan, S., Kohli, P., Jones, D. T., Silver, D., Hassabis, D., & Kavukcuoglu, K. (2020). Improved protein structure prediction using potentials from deep learning. Nature, 577(7792), 706-710. DOI: https://doi.org/10.1038/s41586-019-1923-7
Shukla, S., & Shrivastava, A. (2022). Machine learning in pharmaceuticals: Applications and future directions. Artificial Intelligence in Healthcare, 3(1), 25-35. https://doi.org/10.1016/j.aih.2022.06.001
Topol, E. J. (2019). High-performance medicine: The convergence of human and artificial intelligence. Nature Medicine, 25(1), 44-56. DOI: https://doi.org/10.1038/s41591-018-0300-7
Wang, Y., Tian, L., & Wei, Y. (2021). AI and machine learning for clinical trials: A systematic review. Journal of Clinical Trials, 11(4), 101-110.
Yu, K.-H., & Kohane, I. S. (2022). Framing the challenges of artificial intelligence in medicine. BMJ Health & Care Informatics, 29(1), e100256.
Zhang, Q., & Yang, T. (2020). The future of pharmaceutical innovation: Artificial intelligence and machine learning. European Journal of Pharmaceutical Sciences, 152, 105475. https://doi.org/10.1016/j.ejps.2020.1054
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Dr Farhat ul ain Sonia

This work is licensed under a Creative Commons Attribution 4.0 International License.
With the licence CC-BY, authors retain the copyright, allowing anyone to download, reuse, re-print, modify, distribute, and/or copy their contribution. The work must be properly attributed to its author.
It is not necessary to ask for further permission from the author or journal board.
This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.