Journal of Ayurvedic Herbal and Integrative Medicine

CRITICAL REVIEW OF BHAVPRAKASH NIGHANTU WITH SPECIAL REFERENCE TO PHARMACOVIGILANCE PERSPECTIVE OF MEDICINAL PLANTS AND ITS PRACTICAL APPLICATION IN THERAPEUTICS

Jaynam Prajapati, Dr. Janki Lukhi, Dr. Vidhi Bapna — Tue, 16 Jan 2024 00:00:00 +0000

Introduction: Ayurveda is ancient literature for protecting the health of healthy individual and curing the diseased one. With this aim in World-wide Ayurveda has increased in their practice in form of diets, medicine and routines. As increasing use in western countries, it leads to concern of regarding safety of use. There are various publications which raise concern about the safety of Ayurveda medicines. Today Ayurveda is gathering globally attention with regards to therapeutic option to treat various acute, chronic and non-infectious diseases. Though Ayurveda is practiced for centuries, there is a few of systematic documentation regarding adverse drug reactions (ADRs) occurrence after administration of Aushadha and safety of Aushadha (Ayurvedic medicine). For safety and efficacy of Aushadha, systematic documentation related to ADR’s mentioned in different Samhitas. With respect to Bhavpraksha Nighantu mentioned various ADRs with drugs as mention of Aushadha is given amazing.
Materials and Methods: Bhavprakasha Nighantu was studied critically to look for description of ADRs in medicinal plants (poisonous drugs were excluded) This ADRs were analysed and presented systemically.
Result and Discussion: ADRs aims to achieve qualitative use of drugs and to achieve safety and therapeutic uses to treat with caution. The drugs selected from classics name Bhavprakash Nighantu and their adverse effect with respect to administration of drugs and complication. Use of drugs with safety and prevent ADRs in Ayurvedic medicines
Conclusion: For Understanding the safety of use of Ayurvedic medicine is need in today era with the help of Pharmacovigilance study.

MEDICINAL USES, PRESERVATION, PROMOTION AND CRITICAL STUDY OF DASHMOOLA: AN IMPORTANT COMPONENT DESCRIBED IN AYURVEDA SCRIPTURE

Mon, 26 Feb 2024 00:00:00 +0000

Ayurveda is a scientific method of ancient medicine, in which single and mixed medicines are used multiple times for medicine, in which Dashmoola has its special place. Ashtavarga, Pañcamūla, Trinapanchamoola and Dashmoola are widely used as mixed medicinal components. Dashmoola is made up of two words Dash and Moola, which means "root of ten medicines", i.e., roots of ten medicinal plants are taken in equal proportion. Generally, it is considered to be a combination of the Brihit and Laghu Pañcamūla. Of these ten roots, five roots are of trees known as Bṛhat Pañcamūla and five roots are of bushes known as Laghu Pañcamūla. Bṛhat Pañcamūla includes Bilva [Aegle marmelos (L.) Corrêa], Gambhari (Gmelina arborea Roxb. ex Sm.), Agnimantha (Clerodendrum phlomidis L.f.), Patla [Stereospermum chelonoides (L.f.) DC.], Shyonak [Oroxylum indicum (L.) Kurz] while Laghu Pañcamūla includes Brihati (Solanum indicum L.), Gokharu (Tribulus terrestris L.), Kantakari (Solanum virginianum L.), Prshniparni [Uraria picta (Jacq.) Desv. Ex DC.], Shalaparni [Pleurolobus gangeticus (L.) J.St.-Hil. ex H.Ohashi & K.Ohashi]. Dashmoola is used for the treatment of various diseases, sach as arthritis, asthma, headache, prenatal problems, Parkinson's disease, muscle cramps, lower back pain, etc. In the present review article, habitat, distribution, ecological note, common and vedic nomenclature, flowering and fruiting period, conservation status and medicinal properties of each plant in Dashmoola, have been discussed in detail and Herbarium sheet with field numbers of all plants are available in the Patanjali Research Foundation Herbarium

RECENT RESEARCH ON THE CONCEPT OF THE HRIDAYA IN RACHANA SHARIRA, AND ITS RELATION WITH MODERN ANATOMY

Dr. Mohini Narayan Surwase, Dr. Priyanka Ashok Shinde — Thu, 14 Mar 2024 00:00:00 +0000

Ayurveda states that Hridaya is one of the most important parts of the mortal body. An injury to it may affect it in severe conditions. The specific signs and symptoms of these conditions are well defined in Samhitas. Any kind of trauma or injury to it may lead to death. Therefore, it has been classified under Tri Marma and Dashsa pranayatana. Dwivedi & Kumar (2010). The term Hridaya indicates the organ which regulates the circulation of Prana throughout the body by collecting and diffusing rhythmically. Samhitas state that Hridaya performs several other functions along with the circulation of Prana (blood/ oxygen). These ancient classics mention that Hridaya controls the mortal body, sensations, and powers of logic, becoming the center of life and wit. Hence at one point the term Hridaya is considered as brain. Acharya Charaka and Sushruta have considered the Hridaya as a Koshthanga (organ present in Koshtha/trunk). This easily indicates that Hridaya is nothing but Urastha Hridaya (organ present in Koshtha/trunk). In this composition, an attempt has been made to connect references about Hridaya to modern anatomy through logical analysis of these references.

IN- VITRO ANTIBACTERIAL ACTIVITY OF SPILANTHES ACMELLA (AKARKARA) EXTRACT ON PORPHYROMONAS GINGIVALIS AND AGGREGATIBACTOR ACTINOMYCETEMCOMITANS

Dr. Renu Gaur, Dr. Gazala MP, Dr. Prabhuji MLV — Thu, 21 Mar 2024 00:00:00 +0000

Periodontal diseases are caused by certain bacteria found in the bacterial plaque. Usage of plant-derived antimicrobial agents could serve as an effective alternative treatment against periodontal infections due to continuous rise seen in antibiotic resistance. Spilanthes acmella (S. acmella), a vital medicinal plant has been used for its various properties such as anti- inflammatory, antibacterial, antifungal, antinociceptive, anti-cancerous and hastening wound healing. This study was conducted to assess its antibacterial efficacy against common periodontal pathogens.
Objective: The present study was conducted to assess the antibacterial activity of S. acmella plant extract against Porphyromonas gingivalis (Pg), and Aggregatibactor actinomycetemcomitans (Aa) and determine the presence of various phytochemicals in it.
Materials and Methodology: An extract was prepared using dried S. acmella plant powder and mixed with methanol in 1:1 (w/v) ratio. Determination of minimal inhibitory concentration (MIC) was done by using tube dilution technique and time- kill assay was performed against Pg and Aa. Presence of phytochemicals was checked by thin layer chromatography (TLC) method.
Results: MIC of S. acmella was found to be 40 μg/ml for Pg and 20 μg/ml for Aa within 2 h interval. Various phytochemicals were found in S. acmella extract which may be responsible for its anti- bacterial property.
Conclusion: S. acmella extract shows a significant antibacterial effect against the major periodontal pathogens and hence may be a potential natural alternative for controlling the growth of these bacteria.

ANTIBACTERIAL AND ANTIOXIDANT PROPERTIES OF SOME PLANT EXTRACTS WITH PROPOLIS

Sinem Aydin, Gülşah Kadioğlu — Tue, 28 May 2024 00:00:00 +0000

For many years, plants have been utilized in food, healing materials, and curing for many illnesses. Lately, improvements in biological searches have displayed the notable potential of natural compounds.
Objective: In this study, biological activities of extracts of herbal mixtures with propolis were investigated.
Materials and Methodology: Ethanol and hexane extracts of propolis-Syzygium aromaticum mixture, propolis-Papaver somniferum mixture, propolis-Foeniculum sp. mixture were used in the assays.
Results: Ethanol extracts exhibited higher antibacterial activity compared to hexane extracts. While ethanol extracts inhibited bacterial growth ranges from 7±1.41 mm to 19.5±2.12 mm, hexane extracts showed inhibition zones ranges from 7±0.00 mm to 14±1.41 mm. The maximum and the minimum total phenolic contents were detected in propolis-S. aromaticum ethanol extracts as 389.81±0,001 μg GAE/mL and in propolis-Foeniculum sp. as 100.57±0.012 μg GAE/mL, respectively.
Conclusion: Studied plant extracts with propolis might be an option to synthetic antioxidant and antibacterial compounds.

TULSI THE SACRED HERB AND HOUSEHOLD MEDICINE

Ajit Pal Singh, Rahul Saxena, Suyash Saxena, Neelesh Kumar Maurya — Thu, 30 May 2024 00:00:00 +0000

Tulsi (Ocimum sanctum L) or holy basil, a treasured herb in Indian culture, goes beyond religious significance to provide a wealth of possible health benefits. This article looks into the many facets of Tulsi, including its historical and cultural significance, various variations, and well-documented use as a household medicine in Ayurveda. Scientific research is shedding light on the potential of Tulsi leaves, revealing a diverse array of bioactive substances such as essential oils, flavonoids, and phenolic acids. These substances help to enhance the immune system, relieve respiratory problems, promote digestion, and reduce stress. Traditional Tulsi leaf teas, mixtures, and steam inhalations are easily accessible treatments for common home diseases. Tulsi's research future looks promising and significant numbers of clinical trials are underway to study its efficacy in treating certain health disorders as well as the possible synergistic benefits when mixed with other herbs. Furthermore, research into the genetic variety of different Tulsi types and their distinct therapeutic characteristics holds the key to realising their full potential. Furthermore, Tulsi's simplicity of cultivation at home distinguishes it as a sustainable and accessible source of natural medicine. Efforts to generate standardised Tulsi extracts and formulations could open the door for a more widespread integration into traditional healthcare systems. Tulsi symbolises a unique combination of faith, tradition, and science. As research continues to reveal its potential, Tulsi has enormous promise for the future of natural medicine, providing an easily available and culturally meaningful resource for boosting well-being around the world.

AMELIORATIVE EFFECT OF POLYHERBAL FORMULATION FOR RESTORING LIVER HEALTH: A SYSTEMATIC REVIEW

Fri, 21 Jun 2024 00:00:00 +0000

Herbal medicines have been used for a wide range of ailments since ancient times. Two methods are used in Ayurvedic medicine formulation: one involves employing a single herbal preparation, or multiple combinations of them. Polyherbal formulation is the term for the later. Combining different herbs and plants to treat different medical diseases or to enhance general health is known as polyherbal medicine. Many civilizations all over the world have been using this kind of traditional medicine for centuries, and it is still commonly used today. Due to the active phytoconstituents found in single herbs, which are typically present in minute amounts and occasionally insufficient to produce the desired therapeutic effects, multi herb formulations have a well-established track record. According to scientific research, combining these plants with different potencies may theoretically result in a greater effect than using each plant alone or the sum of their individual effects. Positive interactions between herbs can therefore produce synergistic effect, which may take the form of pharmacokinetic or pharmacodynamic synergism. The great efficacy of polyherbal formulations in treating a wide range of illnesses accounts for their popularity. The growing demand of polyherbal formulations necessitates further scientific investigation in this area.